E-Cigarettes are a very big thing today. My jaw dropped when I read that they have gummy bear and candy flavored ones now. I believe too, that these companies are trying to appeal to young people. Discussions that e-cigarettes are also a gateway form for future cigarette use.
THERE IS NO FORM OF TOBACCO THAT IS GOOD FOR ANYONE. Testing and results have shown the impact of e-cigarettes has upon heart disease.
People think not me, I’m too healthy but they could be destroying their lungs, and increasing the risk of heart attacks. There is no amount of nicotine that can be good for anyone, anytime or anyplace.
In this article I read, obesity has now become a problem for children in the age bracket of 2 to 5 years of age. This is astounding to me.
This is a real problem with children as there is some much time spent on IPads, cell phones and TV games. In turn, team sports have decreased, playing outdoors has decreased and diets are filed with many foods that add calories.
Parents need to take an active role in making sure their children are healthy. That is a tough statement as all parents care about their children.
However, parents set examples every day with this child. Most parents don’t realize that their children do notice them not eating right and exercising. This vision of their parents has a dramatic effect upon the child. A child’s diet is also so critical. They should be eating fruit instead of donuts, salads and vegetables instead of mac and cheese, etc.
Parental influence can change the obesity problem with children.
ABS was founded because there’s a real need for improvements in the way we approach the global heart disease problem. Current methods for treating heart disease aren’t always successful. 7.4 million people die from a heart attack every year. Several new technologies could change that and our innovative new stenting platform is one of them. We hope that human clinical trials and FDA review will show that it could reduce the need for open-heart surgery and improve the quality of life for patients suffering from heart disease.
How the ABS System Works
One of the most difficult procedures for heart surgeons is trying to place stents in branched arteries. The ABS system is designed to simplify the process and replace most open-heart surgeries with a less invasive procedure that can be performed as a day surgery.
Open-heart surgery is a stressful experience for the patient and many suffer depression after their operation. A simple day procedure would reduce their anxiety and allow them to return to their daily lives without a significant recovery period.
The method works by using a dual catheter system to place stents in both the mother and daughter vessels of a branched artery at the same time. The technology is self-aligning as well, to reduce the risk of errors and it’s simple to perform. Most cardiac surgeons will be able to perform the procedure without much training.
A Major Part of the Puzzle
The ABS system isn’t the only breakthrough we hope could aid in reducing deaths from heart disease. New technologies in the areas of Artificial Intelligence, apps, and wearable devices are also part of the solution. It’s not difficult to imagine the risk of death from a heart attack being cut in half in the next decade. Technology is allowing people to live longer and healthier lives. I think that Advanced Bifurcation Systems is a major piece of the puzzle along with these other technologies.
Transient Deterioration From Short Term Increase in Heart Fat Content
Research on the health impact of crash diets conducted at the Oxford Centre for Magnetic Resonance at Oxford University found some interesting results. Obese patients on meal replacement diets were 600 to 800 kcal per day for 56 days. While insulin and fat levels did decrease the first week, heart fat levels increased about 44% in the study in the first week. In the first week body fat (of course), visceral fat and liver fat all fell and the patients displayed improvements in insulin resistance, fasting total cholesterol, triglycerides, glucose and blood pressure.
Short Term Stresses On Heart Possible
By the end of the study the heart fat levels had improved beyond where they had started so these diets do display a number of health benefits. Doctors warned that people with heart disease or other cardiovascular conditions should discuss these diets with a health care professional before hand to ensure they can handle the short term impacts.
Dr Rayner said: “The metabolic improvements with a very low calorie diet, such as a reduction in liver fat and reversal of diabetes, would be expected to improve heart function. Instead, heart function got worse in the first week before starting to improve.”
Stress From Environmental Commotion May Be The Cause
Researches have found linkages between environmental sounds, such as those from airplanes and road noise can contribute to the risk factor for heart disease. Research like this is critical since 800 people every minute die of heart disease and that number will go up more than 25% in about 7 years. They linked risk factors including diabetes and hypertension. Turbulent sounds are associated with oxidative stress, vascular dysfunction, autonomic imbalance and metabolic abnormalities.
Thomas Munzel, MD, lead author of the review and director of the Department of Internal Medicine at University Medical Center Mainz, Johannes Cutenberg University, Mainz, Germany, said, “as the percentage of the population exposed to detrimental levels of transportation noise are rising, new developments and legislation to reduce noise are important for public health.”
I’m in the Air China Club in the Beijing airport waiting for my flight back to Los Angeles. In Beijing it is 12:28 pm on Friday February 2nd. My flight arrives at LAX at 11am on Friday February 2nd. I am saddened by leaving this land of the future.
Here in China the next two weeks will be basically a long holiday. Almost everything is closed for the Chinese New Year celebrations. Everyone travels home, and it is one of the major holidays of the year in China.
This morning I had two last meetings and these both were excellent. This was a very successful trip to China for ABS. I expect to be back again in March. China is a dynamic and exciting place. It is an excellent place to do business and it is a critically important market for ABS.
The trip has been very important for ABS and a great experience for me as well. I have come to appreciate both the history and culture of China. I am committed to learning as much Mandarin as I possibly can and will be able to use a lot more of it on my next trip. I would recommend every parent or grandparent to have kids begin to learn Mandarin. It is the language of the future. In business and life, you better get acquainted with China.
I made it to Beijing and am really enjoying the city. The people here are very friendly as everyone smiles and appears very upbeat. Everywhere I go locals have been very willing to help with anything I have needed. It is a surprisingly friendly reception for such a large city.
An Ocean of Bikes – Go Ahead and Take One
Beijing is very clean and very, very busy. There are remarkably large numbers of cars, motor scooters and thousands of bikes. It sometimes feels like an ocean of bikes. Bikes sit on every corner and people just ride one and drop it off wherever their destination might take them.
I had 3 meetings this morning. All of them went well and I am excited at the scope of the opportunities in China. Heart disease is a global pandemic killing 17M people a year. In many rapidly developing economies like China, aging populations, more western diets, more dairy and red meats and more sedentary office jobs mean that we need new tools to address heart disease in all its forms.
Talent, Capital and Opportunity
Beijing has a highly skilled work force with many university educated engineers. We discussed a facility in Shenzhen with potential for a joint venture with a fund in China. Shenzhen is in southeastern China and links Hong Kong to China’s mainland.
Meeting this afternoon with State Development & Investment Corporation (SDIC). SDIC is the largest Chinese state owned investment fund and they last reported assets of over 461.7 billion RMB yuan a few years ago.
That is it from Beijing today. I have dinner tonight and will finish late. Tomorrow is Friday here and I have more meetings in the morning and then I am headed to the airport and back to LA.
It is Wednesday night in China. I checked out of my hotel and went to the train station in Shanghai, so I can travel to Beijing. The train station was amazing. There were more people than a sold-out USC Football game at the LA Coliseum!
I am looking forward to my trip to Beijing. I have a very full schedule including a business dinner and investor meetings Thursday and Friday. I still hope to take
in as much of the city and culture as I can.
Travel in China heating up because the Chinese New Year is this Friday. Thursday night many Chinese will hold reunion dinners and their family members will travel across the country. This annual celebration has been called the largest annual human migration in the world.
I feel lucky to be in China for their New Year celebrations. Friday marks the end of the year of the Rooster and the beginning of the year of the Dog. Many will decorate their windows and doors with red color paper-cuts and wishes for the new year like “good fortune” or “happiness”, “wealth”, and “longevity”. They also celebrate with firecrackers and by giving each other money in red paper envelopes for luck.
Luck is very important in Chinese culture. 8 is the luckiest number in Chinese culture because 八 sounds like 發 (fa), which means “wealth”, “fortune”, and “prosper” in Chinese. I will take that as a sign that my 8 days in China will be very productive for ABS.
Today was my third and final day in Shanghai. Tomorrow morning, I leave for Beijing. I am looking forward to seeing the city and am excited at how well the trip has gone.
Most of today I met with some great people from the global company Terumo Corporation.
Terumo is a medical device company with over $4B USD in annual sales. They have lines of business including general hospital devices and supplies such as catheters, thermometers and monitors as well as a business that produces a broad range of blood management devices and supplies. And, of course, they have a cardiac and vascular business as well.
We started out early this morning and covered everything about ABS and our platform. After a few hours we dialed in Doctor Mehran Khorsandi, ABS cofounder and chief medical officer, to cover some questions that were specific to interventional cardiology. Again, after Mehran spoke he answered their questions and left our hosts with no doubt about the ability of cardiologists to transfer to the ABS system. I look forward to follow-up meetings with Terumo at their corporate headquarters in Japan.
This was our second set of meetings with Terumo. We last met with them at the JP Morgan in California a few weeks ago. We also met today with Fosun Pharma and Lilly Asia Ventures. Both meetings were good, and their representatives were well informed on the Asian market. We discussed the regional potential for companies like ABS. Heart disease is a major global problem and kills over 47,000 people a day. So, the hard work by the people at companies like Advanced Bifurcation, Terumo and Fosun Pharma is important to everyone.
Today was a very busy day and the jet lag is catching up with me a bit.
Hěn-gāo-xīng-rèn-shí-nǐ – Now Let’s Talk About A Global Killer
Monday was exciting because it was my first experience with Shanghai on a workday.
Our first meeting was at China Renaissance Group. It was a large, modern office building but everyone was wearing overcoats or scarfs because the building had minimal heating. So, people bundled up, except for me, and it did not seem to bother them. The meeting was excellent, and some large opportunities lie ahead for ABS.
We had five more meetings today and then we have a business dinner meeting tonight. I am also starting to be a fan of Chinese food and, after many attempts, I can finally use chopsticks credibly.
We met with many excellent funds and got very excellent feedback today on Advanced Bifurcation Systems. One thing that shocks people is the scope of the public health and economic costs of heart disease.
Cardiovascular disease is a global pandemic and we can do so much more to help. CVDs are the number 1 cause of death worldwide. In 2015 the WHO estimates that 17.7 million people died. Cardiovascular disease is 31% of all global deaths. This includes 7.4 million from coronary heart disease and 6.7 million from stroke.
Two that were very interesting were C-Bridge capital and Lyfe Capital. Both were excited about the opportunity ahead for ABS and in fact Lyfe wants to have us meet one of their investment portfolio companies. There is something here that might be beneficial to both us and their portfolio company that could give ABS significant exposure in Asia.
We were very lucky to have Dr. Khorsandi on both calls. He was in LA (16 hours time difference). Our meetings included MDs, so Dr. K provided a more credible depth of detail to the conversation. We have lots of follow-up but the opportunity is very exciting.
All in, today was a very good day even though I was freezing all day long. Now it is off to my dinner meeting at 6:30 pm local time. We are having Japanese food. This has been as wonderful day with lots of excitement. It is fun to talk about the mission of the company and every conversation makes me even more proud of ABS and what we hope to accomplish.